1176 A fractional ultrasound microneedle array for drug delivery and skin disease treatment

Transdermal drug delivery has the potential to provide many practical and clinical advantages including sustained release of drugs, avoidance first pass-hepatic metabolism, patient-friendly. However, efficiency this administration long been hindered by skin barrier. The upper layer skin, stratum corneum (SC), provides a strong barrier permeation most drugs into deeper dermal layers, which limits uptake absorption dosage. Energetic actuation is good means facilitate delivery. Sonophoresis as an external disrupts temporarily enhance penetration through driving forces in safe manner. Despite providing energy, it does not enable rapid with internal force energy deep dermis. Other disadvantages include lesion surface additional coupling agents, low utilization, (caused squeezed intercellular space).A highly efficient strategy clinically important. We propose new system named fractional ultrasound (FUS), achieves suitable balance between effective safety skin. Without surfactant, can concentrate tissues greatly improve penetration. applied deliver 5-ALA combination photodynamic therapy treatment successfully cured several patients hand foot warts. Our solves problem squeezing changing physical structure that exists low-frequency sonophoresis. FUS promises for hypertrophic lesions other disorders.